Fascination About indazole synthesis
Substitution at R3 that has a halogen or alkoxy group (74f–74i) brought about a slight rise in cellular potency With all the halide analogs (74g–h) exhibiting optimum the potency from the group. Even further optimization brought about the discovery of 74i–j, with 74k as probably the most Lively compound in the collection (pIC50 = six.77) with